Whole-Cell Screen of Fragment Library Identifies Gut Microbiota Metabolite Indole Propionic Acid as Antitubercular

Several key antituberculosis drugs, including pyrazinamide, with a molecular mass of 123.1 g/mol, are smaller than the usual drug-like molecules. Current drug discovery efforts focus on the screening of larger compounds with molecular masses centered around 400 to 500 g/mol. Fragment (molecular mass...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Negatu, Dereje A., Liu, Joe J. J., Zimmerman, Matthew, Kaya, Firat, Dartois, Véronique, Aldrich, Courtney C., Gengenbacher, Martin, Dick, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826148/
https://ncbi.nlm.nih.gov/pubmed/29229639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01571-17
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