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Stress-activated MAPKs and CRM1 regulate the subcellular localization of Net1A to control cell motility and invasion

The neuroepithelial cell transforming gene 1A (Net1A, an isoform of Net1) is a RhoA subfamily guanine nucleotide exchange factor (GEF) that localizes to the nucleus in the absence of stimulation, preventing it from activating RhoA. Once relocalized in the cytosol, Net1A stimulates cell motility and...

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Pubblicato in:J Cell Sci
Autori principali: Ulu, Arzu, Oh, Wonkyung, Zuo, Yan, Frost, Jeffrey A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Ltd 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826041/
https://ncbi.nlm.nih.gov/pubmed/29361525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.204644
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