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Acetylation of the RhoA GEF Net1A controls its subcellular localization and activity

Net1 isoform A (Net1A) is a RhoA GEF that is required for cell motility and invasion in multiple cancers. Nuclear localization of Net1A negatively regulates its activity, and we have recently shown that Rac1 stimulates Net1A relocalization to the plasma membrane to promote RhoA activation and cytosk...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Song, Eun Hyeon, Oh, Wonkyung, Ulu, Arzu, Carr, Heather S., Zuo, Yan, Frost, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342578/
https://ncbi.nlm.nih.gov/pubmed/25588829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.158121
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