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Acetylation of the RhoA GEF Net1A controls its subcellular localization and activity
Net1 isoform A (Net1A) is a RhoA GEF that is required for cell motility and invasion in multiple cancers. Nuclear localization of Net1A negatively regulates its activity, and we have recently shown that Rac1 stimulates Net1A relocalization to the plasma membrane to promote RhoA activation and cytosk...
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| Publicat a: | J Cell Sci |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Company of Biologists
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4342578/ https://ncbi.nlm.nih.gov/pubmed/25588829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.158121 |
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