The G protein-coupled receptor Gpr161 regulates forelimb formation, limb patterning and skeletal morphogenesis in a primary cilium-dependent manner

The role of basal suppression of the sonic hedgehog (Shh) pathway and its interaction with Indian hedgehog (Ihh) signaling during limb/skeletal morphogenesis is not well understood. The orphan G protein-coupled receptor Gpr161 localizes to primary cilia and functions as a negative regulator of Shh s...

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Vydáno v:Development
Hlavní autoři: Hwang, Sun-hee, White, Kevin A., Somatilaka, Bandarigoda N., Shelton, John M., Richardson, James A., Mukhopadhyay, Saikat
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825871/
https://ncbi.nlm.nih.gov/pubmed/29222391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.154054
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