ENDOTYPE TRANSITIONS DURING THE ACUTE PHASE OF PEDIATRIC SEPTIC SHOCK REFLECT CHANGING RISK AND TREATMENT RESPONSE

OBJECTIVE: We previously identified septic shock endotypes A and B based on 100 genes reflecting adaptive immunity and glucocorticoid receptor signaling. The endotypes differ with respect to outcome and corticosteroid responsiveness. We determined whether endotypes change during the initial three da...

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Pubblicato in:Crit Care Med
Autori principali: Wong, Hector R., Cvijanovich, Natalie Z., Anas, Nick, Allen, Geoffrey L., Thomas, Neal J., Bigham, Michael T., Weiss, Scott L., Fitzgerald, Julie C., Checchia, Paul A., Meyer, Keith, Quasney, Michael, Hall, Mark, Gedeit, Rainer, Freishtat, Robert J., Nowak, Jeffrey, Lutfi, Riad, Gertz, Shira, Grunwell, Jocelyn R., Lindsell, Christopher J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825261/
https://ncbi.nlm.nih.gov/pubmed/29252929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000002932
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