ENDOTYPE TRANSITIONS DURING THE ACUTE PHASE OF PEDIATRIC SEPTIC SHOCK REFLECT CHANGING RISK AND TREATMENT RESPONSE

OBJECTIVE: We previously identified septic shock endotypes A and B based on 100 genes reflecting adaptive immunity and glucocorticoid receptor signaling. The endotypes differ with respect to outcome and corticosteroid responsiveness. We determined whether endotypes change during the initial three da...

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Detalhes bibliográficos
Publicado no:Crit Care Med
Main Authors: Wong, Hector R., Cvijanovich, Natalie Z., Anas, Nick, Allen, Geoffrey L., Thomas, Neal J., Bigham, Michael T., Weiss, Scott L., Fitzgerald, Julie C., Checchia, Paul A., Meyer, Keith, Quasney, Michael, Hall, Mark, Gedeit, Rainer, Freishtat, Robert J., Nowak, Jeffrey, Lutfi, Riad, Gertz, Shira, Grunwell, Jocelyn R., Lindsell, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825261/
https://ncbi.nlm.nih.gov/pubmed/29252929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000002932
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