Engineered aglycosylated full-length IgG Fc variants exhibiting improved FcγRIIIa binding and tumor cell clearance

FcγRIIIa, which is predominantly expressed on the surface of natural killer cells, plays a key role in antibody-dependent cell-mediated cytotoxicity (ADCC), a major effector function of therapeutic IgG antibodies that results in the death of aberrant cells. Despite the potential uses of aglycosylate...

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Publicado no:MAbs
Main Authors: Jo, Migyeong, Kwon, Hyeong Sun, Lee, Kwang-Hoon, Lee, Ji Chul, Jung, Sang Taek
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825196/
https://ncbi.nlm.nih.gov/pubmed/29173039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1402995
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