Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes

B cell follicles in secondary lymphoid tissues represent an immune privileged sanctuary for AIDS viruses, in part because cytotoxic CD8(+) T cells are mostly excluded from entering the follicles that harbor infected T follicular helper (T(FH)) cells. We studied the effects of native heterodimeric IL...

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Gepubliceerd in:PLoS Pathog
Hoofdauteurs: Watson, Dionysios C., Moysi, Eirini, Valentin, Antonio, Bergamaschi, Cristina, Devasundaram, Santhi, Fortis, Sotirios P., Bear, Jenifer, Chertova, Elena, Bess, Julian, Sowder, Ray, Venzon, David J., Deleage, Claire, Estes, Jacob D., Lifson, Jeffrey D., Petrovas, Constantinos, Felber, Barbara K., Pavlakis, George N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825155/
https://ncbi.nlm.nih.gov/pubmed/29474450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006902
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