Heterodimeric IL-15 regulates the differentiation and survival of different populations of memory T cells and the balance of effector and regulatory cells

Eitemau Tebyg

• Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum
  gan: Bergamaschi, Cristina, et al.
  Cyhoeddwyd: (2012)
• Heterodimeric IL-15 Treatment Enhances Tumor Infiltration, Persistence and Effector Functions of Adoptively Transferred Tumor-specific T Cells in the Absence of Lymphodepletion
  gan: Ng, Sinnie Sin Man, et al.
  Cyhoeddwyd: (2016)
• Differential effects of IL-15 on the generation, maintenance and cytotoxic potential of adaptive cellular responses induced by DNA vaccination
  gan: Li, Jinyao, et al.
  Cyhoeddwyd: (2015)
• Characterization and Favorable in Vivo Properties of Heterodimeric Soluble IL-15·IL-15Rα Cytokine Compared to IL-15 Monomer
  gan: Chertova, Elena, et al.
  Cyhoeddwyd: (2013)
• Intramuscular delivery of heterodimeric IL-15 DNA in macaques produces systemic levels of bioactive cytokine inducing proliferation of NK and T cells
  gan: Bergamaschi, C, et al.
  Cyhoeddwyd: (2015)