Intramuscular delivery of heterodimeric IL-15 DNA in macaques produces systemic levels of bioactive cytokine inducing proliferation of NK and T cells

Interleukin-15 (IL-15) is a common γ-chain cytokine that has a significant role in the activation and proliferation of T and NK cells and holds great potential in fighting infection and cancer. We have previously shown that bioactive IL-15 in vivo comprises a complex of the IL-15 chain with the solu...

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Publicat a:Gene Ther
Autors principals: Bergamaschi, C, Kulkarni, V, Rosati, M, Alicea, C, Jalah, R, Chen, S, Bear, J, Sardesai, N Y, Valentin, A, Felber, B K, Pavlakis, G N
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289118/
https://ncbi.nlm.nih.gov/pubmed/25273353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2014.84
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