Dysregulation of the IFN-γ-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia

T cell large granular lymphocyte leukemia (T-LGLL) is a rare incurable disease that is characterized by defective apoptosis of cytotoxic CD8+ T cells. Chronic activation of the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway is a hallmark of T-LGLL. One manifestation...

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Veröffentlicht in:PLoS One
Hauptverfasser: Kulling, Paige M., Olson, Kristine C., Hamele, Cait E., Toro, Mariella F., Tan, Su-Fern, Feith, David J., Loughran, Thomas P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825082/
https://ncbi.nlm.nih.gov/pubmed/29474442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193429
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