Large granular lymphocyte leukemia serum and corresponding hematological parameters reveal unique cytokine and sphingolipid biomarkers and associations with STAT3 mutations

Large granular lymphocyte (LGL) leukemia is a rare hematological disorder with expansion of the T‐cell or natural killer (NK) cell lineage. Signal transducer and activator of transcription 3 (STAT3) exhibits somatic activating mutations in 30%‐40% of LGL leukemia cases. Transcriptional targets of ST...

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Publicado no:Cancer Med
Main Authors: Olson, Kristine C., Moosic, Katharine B., Jones, Marieke K., Larkin, Paige M. K., Olson, Thomas L., Toro, Mariella F., Fox, Todd E., Feith, David J., Loughran, Thomas P.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Clinical Cancer Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7520360/
https://ncbi.nlm.nih.gov/pubmed/32710512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.3246
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