Factor XII and uPAR upregulate neutrophil functions to influence wound healing

Coagulation factor XII (FXII) deficiency is associated with decreased neutrophil migration, but the mechanisms remain uncharacterized. Here, we examine how FXII contributes to the inflammatory response. In 2 models of sterile inflammation, FXII-deficient mice (F12(–/–)) had fewer neutrophils recruit...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Stavrou, Evi X., Fang, Chao, Bane, Kara L., Long, Andy T., Naudin, Clément, Kucukal, Erdem, Gandhi, Agharnan, Brett-Morris, Adina, Mumaw, Michele M., Izadmehr, Sudeh, Merkulova, Alona, Reynolds, Cindy C., Alhalabi, Omar, Nayak, Lalitha, Yu, Wen-Mei, Qu, Cheng-Kui, Meyerson, Howard J., Dubyak, George R., Gurkan, Umut A., Nieman, Marvin T., Sen Gupta, Anirban, Renné, Thomas, Schmaier, Alvin H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2018
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824869/
https://ncbi.nlm.nih.gov/pubmed/29376892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92880
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