Factor XII and uPAR upregulate neutrophil functions to influence wound healing

Coagulation factor XII (FXII) deficiency is associated with decreased neutrophil migration, but the mechanisms remain uncharacterized. Here, we examine how FXII contributes to the inflammatory response. In 2 models of sterile inflammation, FXII-deficient mice (F12(–/–)) had fewer neutrophils recruit...

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Publicado en:J Clin Invest
Autores principales: Stavrou, Evi X., Fang, Chao, Bane, Kara L., Long, Andy T., Naudin, Clément, Kucukal, Erdem, Gandhi, Agharnan, Brett-Morris, Adina, Mumaw, Michele M., Izadmehr, Sudeh, Merkulova, Alona, Reynolds, Cindy C., Alhalabi, Omar, Nayak, Lalitha, Yu, Wen-Mei, Qu, Cheng-Kui, Meyerson, Howard J., Dubyak, George R., Gurkan, Umut A., Nieman, Marvin T., Sen Gupta, Anirban, Renné, Thomas, Schmaier, Alvin H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824869/
https://ncbi.nlm.nih.gov/pubmed/29376892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92880
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