Factor XII and uPAR upregulate neutrophil functions to influence wound healing

Coagulation factor XII (FXII) deficiency is associated with decreased neutrophil migration, but the mechanisms remain uncharacterized. Here, we examine how FXII contributes to the inflammatory response. In 2 models of sterile inflammation, FXII-deficient mice (F12(–/–)) had fewer neutrophils recruit...

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Publicat a:J Clin Invest
Autors principals: Stavrou, Evi X., Fang, Chao, Bane, Kara L., Long, Andy T., Naudin, Clément, Kucukal, Erdem, Gandhi, Agharnan, Brett-Morris, Adina, Mumaw, Michele M., Izadmehr, Sudeh, Merkulova, Alona, Reynolds, Cindy C., Alhalabi, Omar, Nayak, Lalitha, Yu, Wen-Mei, Qu, Cheng-Kui, Meyerson, Howard J., Dubyak, George R., Gurkan, Umut A., Nieman, Marvin T., Sen Gupta, Anirban, Renné, Thomas, Schmaier, Alvin H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824869/
https://ncbi.nlm.nih.gov/pubmed/29376892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92880
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