Directed evolution of SIRT6 for improved deacylation and glucose homeostasis maintenance

Mammalian SIRT6 is a well-studied histone deacetylase that was recently shown to exhibit high protein deacylation activity enabling the removal of long chain fatty acyl groups from proteins. SIRT6 was shown to play key roles in cellular homeostasis by regulating a variety of cellular processes inclu...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Gertman, Or, Omer, Dotan, Hendler, Adi, Stein, Daniel, Onn, Lior, Khukhin, Yana, Portillo, Miguel, Zarivach, Raz, Cohen, Haim Y., Toiber, Debra, Aharoni, Amir
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824787/
https://ncbi.nlm.nih.gov/pubmed/29476161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21887-9
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