Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2

Tumor necrosis factor (TNF) can drive inflammation, cell survival, and death. While ubiquitylation-, phosphorylation-, and nuclear factor κB (NF-κB)-dependent checkpoints suppress the cytotoxic potential of TNF, it remains unclear whether ubiquitylation can directly repress TNF-induced death. Here,...

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Publicado no:Mol Cell
Main Authors: Annibaldi, Alessandro, Wicky John, Sidonie, Vanden Berghe, Tom, Swatek, Kirby N., Ruan, Jianbin, Liccardi, Gianmaria, Bianchi, Katiuscia, Elliott, Paul R., Choi, Sze Men, Van Coillie, Samya, Bertin, John, Wu, Hao, Komander, David, Vandenabeele, Peter, Silke, John, Meier, Pascal
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823975/
https://ncbi.nlm.nih.gov/pubmed/29452637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.027
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