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Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2

Tumor necrosis factor (TNF) can drive inflammation, cell survival, and death. While ubiquitylation-, phosphorylation-, and nuclear factor κB (NF-κB)-dependent checkpoints suppress the cytotoxic potential of TNF, it remains unclear whether ubiquitylation can directly repress TNF-induced death. Here,...

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Bibliografiske detaljer
Udgivet i:Mol Cell
Main Authors: Annibaldi, Alessandro, Wicky John, Sidonie, Vanden Berghe, Tom, Swatek, Kirby N., Ruan, Jianbin, Liccardi, Gianmaria, Bianchi, Katiuscia, Elliott, Paul R., Choi, Sze Men, Van Coillie, Samya, Bertin, John, Wu, Hao, Komander, David, Vandenabeele, Peter, Silke, John, Meier, Pascal
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823975/
https://ncbi.nlm.nih.gov/pubmed/29452637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.027
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