NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction

The bioenergetics and molecular determinants of the metabolic response to mitochondrial dysfunction are incompletely understood, in part due to a lack of appropriate isogenic cellular models of primary mitochondrial defects. Here, we capitalize on a recently developed cell model with defined levels...

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Опубликовано в: :Mol Cell
Главные авторы: Gaude, Edoardo, Schmidt, Christina, Gammage, Payam A., Dugourd, Aurelien, Blacker, Thomas, Chew, Sew Peak, Saez-Rodriguez, Julio, O’Neill, John S., Szabadkai, Gyorgy, Minczuk, Michal, Frezza, Christian
Формат: Artigo
Язык:Inglês
Опубликовано: Cell Press 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823973/
https://ncbi.nlm.nih.gov/pubmed/29452638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.034
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