NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction

The bioenergetics and molecular determinants of the metabolic response to mitochondrial dysfunction are incompletely understood, in part due to a lack of appropriate isogenic cellular models of primary mitochondrial defects. Here, we capitalize on a recently developed cell model with defined levels...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Gaude, Edoardo, Schmidt, Christina, Gammage, Payam A., Dugourd, Aurelien, Blacker, Thomas, Chew, Sew Peak, Saez-Rodriguez, Julio, O’Neill, John S., Szabadkai, Gyorgy, Minczuk, Michal, Frezza, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823973/
https://ncbi.nlm.nih.gov/pubmed/29452638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.034
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