Inhibiting checkpoint kinase 1 protects bone from bone resorption by mammary tumor in a mouse model

DNA damage response plays a critical role in tumor growth, but little is known about its potential role in bone metabolism. We employed selective inhibitors of Chk1 and examined their effects on the proliferation and migration of mammary tumor cells as well as the development of osteoblasts and oste...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Liu, Shengzhi, Liu, Yang, Minami, Kazumasa, Chen, Andy, Wan, Qiaoqiao, Yin, Yukun, Gan, Liangying, Xu, Aihua, Matsuura, Nariaki, Koizumi, Masahiko, Liu, Yunlong, Na, Sungsoo, Li, Jiliang, Nakshatri, Harikrishna, Li, Bai-Yan, Yokota, Hiroki
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823640/
https://ncbi.nlm.nih.gov/pubmed/29507695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24286
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