Inhibiting checkpoint kinase 1 protects bone from bone resorption by mammary tumor in a mouse model

DNA damage response plays a critical role in tumor growth, but little is known about its potential role in bone metabolism. We employed selective inhibitors of Chk1 and examined their effects on the proliferation and migration of mammary tumor cells as well as the development of osteoblasts and oste...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Liu, Shengzhi, Liu, Yang, Minami, Kazumasa, Chen, Andy, Wan, Qiaoqiao, Yin, Yukun, Gan, Liangying, Xu, Aihua, Matsuura, Nariaki, Koizumi, Masahiko, Liu, Yunlong, Na, Sungsoo, Li, Jiliang, Nakshatri, Harikrishna, Li, Bai-Yan, Yokota, Hiroki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823640/
https://ncbi.nlm.nih.gov/pubmed/29507695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24286
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