Inhibiting checkpoint kinase 1 protects bone from bone resorption by mammary tumor in a mouse model

DNA damage response plays a critical role in tumor growth, but little is known about its potential role in bone metabolism. We employed selective inhibitors of Chk1 and examined their effects on the proliferation and migration of mammary tumor cells as well as the development of osteoblasts and oste...

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Vydáno v:Oncotarget
Hlavní autoři: Liu, Shengzhi, Liu, Yang, Minami, Kazumasa, Chen, Andy, Wan, Qiaoqiao, Yin, Yukun, Gan, Liangying, Xu, Aihua, Matsuura, Nariaki, Koizumi, Masahiko, Liu, Yunlong, Na, Sungsoo, Li, Jiliang, Nakshatri, Harikrishna, Li, Bai-Yan, Yokota, Hiroki
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823640/
https://ncbi.nlm.nih.gov/pubmed/29507695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24286
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