Lysosomal Cholesterol Activates mTORC1 via an SLC38A9-Niemann Pick C1 Signaling Complex

The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that becomes activated at the lysosome in response to nutrient cues. Here we identify cholesterol, an essential building block for cellular growth, as a nutrient input that drives mTORC1 recruitment an...

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Publicat a:Science
Autors principals: Castellano, Brian M., Thelen, Ashley M., Moldavski, Ofer, Feltes, McKenna, van der Welle, Reini E. N., Mydock-McGrane, Laurel, Jiang, Xuntian, van Eijkeren, Robert J, Davis, Oliver B., Louie, Sharon M., Perera, Rushika M., Covey, Douglas, Nomura, Daniel K., Ory, Daniel S., Zoncu, Roberto
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823611/
https://ncbi.nlm.nih.gov/pubmed/28336668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aag1417
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