Cyclic trans-phosphorylation in a homodimer as the predominant mechanism of EGFRvIII action and regulation

Despite intensive research no therapies targeted against the oncogenic EGFRvIII are present in the clinic. One of the reasons is the elusive nature of the molecular structure and activity of the truncated receptor. The recent publications indicate the EGF-bound wild-type EGFR to trans-phosphorylate...

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Vydáno v:Oncotarget
Hlavní autoři: Stec, Wojciech, Rosiak, Kamila, Treda, Cezary, Smolarz, Maciej, Peciak, Joanna, Pacholczyk, Marcin, Lenart, Anna, Grzela, Dawid, Stoczynska-Fidelus, Ewelina, Rieske, Piotr
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823601/
https://ncbi.nlm.nih.gov/pubmed/29492217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24058
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