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Cyclic trans-phosphorylation in a homodimer as the predominant mechanism of EGFRvIII action and regulation
Despite intensive research no therapies targeted against the oncogenic EGFRvIII are present in the clinic. One of the reasons is the elusive nature of the molecular structure and activity of the truncated receptor. The recent publications indicate the EGF-bound wild-type EGFR to trans-phosphorylate...
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| Publicado en: | Oncotarget |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Impact Journals LLC
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5823601/ https://ncbi.nlm.nih.gov/pubmed/29492217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24058 |
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