Cyclic trans-phosphorylation in a homodimer as the predominant mechanism of EGFRvIII action and regulation

Despite intensive research no therapies targeted against the oncogenic EGFRvIII are present in the clinic. One of the reasons is the elusive nature of the molecular structure and activity of the truncated receptor. The recent publications indicate the EGF-bound wild-type EGFR to trans-phosphorylate...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Stec, Wojciech, Rosiak, Kamila, Treda, Cezary, Smolarz, Maciej, Peciak, Joanna, Pacholczyk, Marcin, Lenart, Anna, Grzela, Dawid, Stoczynska-Fidelus, Ewelina, Rieske, Piotr
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823601/
https://ncbi.nlm.nih.gov/pubmed/29492217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24058
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