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Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase
The activity of DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1), which excises oxidized base 8-oxoguanine (8-OG) from DNA, is closely linked to mutagenesis, genotoxicity, cancer, and inflammation. To test the roles of OGG1-mediated repair in these pathways, we have undertaken the development o...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5823510/ https://ncbi.nlm.nih.gov/pubmed/29376367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b09316 |
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