High-efficiency RNA-based reprogramming of human primary fibroblasts

Induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine; however, their potential clinical application is hampered by the low efficiency of somatic cell reprogramming. Here, we show that the synergistic activity of synthetic modified mRNAs encoding reprogramming factors a...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kogut, Igor, McCarthy, Sandra M., Pavlova, Maryna, Astling, David P., Chen, Xiaomi, Jakimenko, Ana, Jones, Kenneth L., Getahun, Andrew, Cambier, John C., Pasmooij, Anna M. G., Jonkman, Marcel F., Roop, Dennis R., Bilousova, Ganna
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821705/
https://ncbi.nlm.nih.gov/pubmed/29467427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03190-3
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