High-efficiency RNA-based reprogramming of human primary fibroblasts

Induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine; however, their potential clinical application is hampered by the low efficiency of somatic cell reprogramming. Here, we show that the synergistic activity of synthetic modified mRNAs encoding reprogramming factors a...

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Publicado en:Nat Commun
Autores principales: Kogut, Igor, McCarthy, Sandra M., Pavlova, Maryna, Astling, David P., Chen, Xiaomi, Jakimenko, Ana, Jones, Kenneth L., Getahun, Andrew, Cambier, John C., Pasmooij, Anna M. G., Jonkman, Marcel F., Roop, Dennis R., Bilousova, Ganna
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821705/
https://ncbi.nlm.nih.gov/pubmed/29467427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03190-3
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