Restoration of the type I IFN–IL-1 balance through targeted blockade of PTGER4 inhibits autoimmunity in NOD mice

Type I IFN (IFN-I) dysregulation contributes to type 1 diabetes (T1D) development, and although increased IFN-I signals are pathogenic at the initiation of autoimmune diabetes, IFN-I dysregulation at later pathogenic stages more relevant for therapeutic intervention is not well understood. We discov...

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Bibliografische gegevens
Gepubliceerd in:JCI Insight
Hoofdauteurs: Rahman, M. Jubayer, Rodrigues, Kameron B., Quiel, Juan A., Liu, Yi, Bhargava, Vipul, Zhao, Yongge, Hotta-Iwamura, Chie, Shih, Han-Yu, Lau-Kilby, Annie W., Malloy, Allison M.W., Thoner, Timothy W., Tarbell, Kristin V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821190/
https://ncbi.nlm.nih.gov/pubmed/29415894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97843
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