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CD8(+) dendritic cell-mediated tolerance of autoreactive CD4(+) T cells is deficient in NOD mice and can be corrected by blocking CD40L
DCs are important mediators of peripheral tolerance for the prevention of autoimmunity. Chimeric αDEC-205 antibodies with attached antigens allow in vivo antigen-specific stimulation of T cells by CD8(+) DCs, resulting in tolerance in nonautoimmune mice. However, it is not clear whether DC-mediated...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Leukocyte Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3896656/ https://ncbi.nlm.nih.gov/pubmed/24082013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0113013 |
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