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Despite Increased Type 1 IFN, Autoimmune Nonobese Diabetic Mice Display Impaired Dendritic Cell Response to CpG and Decreased Nuclear Localization of IFN-Activated STAT1
Innate immune signals help break self-tolerance to initiate autoimmune diseases such as type 1 diabetes, but innate contributions to subsequent regulation of disease progression are less clear. Most studies have measured in vitro innate responses of GM-CSF dendritic cells (DCs) that are functionally...
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Pubblicato in: | J Immunol |
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Autori principali: | , , , , , , , , |
Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
2016
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Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5074843/ https://ncbi.nlm.nih.gov/pubmed/26826238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501239 |
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