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Low CD25 on autoreactive Tregs impairs tolerance via low dose IL-2 and antigen delivery
Dendritic cell (DC)-mediated T cell tolerance deficiencies contribute to the pathogenesis of autoimmune diseases such as type 1 diabetes. Delivering self-antigen to dendritic-cell inhibitory receptor-2 (DCIR2)(+) DCs can delay but not completely block diabetes development in NOD mice. These DCIR2-ta...
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| Publicado no: | J Autoimmun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5949247/ https://ncbi.nlm.nih.gov/pubmed/29439835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2018.01.005 |
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