Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells

Cancer stem cells (CSCs) — known to be resistant to genotoxic radiation and chemotherapy — are fundamental to therapy failure and cancer relapse. Here, we reveal that glioma CSCs are hypersensitive to radiation, but a temporal DNA repair mechanism converts the intrinsic sensitivity to genomic instab...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Wang, Yanling, Xu, Haineng, Liu, Tianrun, Huang, Menggui, Butter, Param-Puneet, Li, Chunsheng, Zhang, Lin, Kao, Gary D., Gong, Yanqing, Maity, Amit, Koumenis, Constantinos, Fan, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821187/
https://ncbi.nlm.nih.gov/pubmed/29415883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98096
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