Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia

The PI3K/Akt pathway is activated in many cancers; therefore, we investigated NVP-BEZ235, a dual PI3K/mTOR inhibitor. BEZ235 was more potent than either the mTOR inhibitor rapamycin or the PI3K inhibitor LY294002 in blocking HIF-1α induction. BEZ235 decreases protein translation, and 7-methyl GTP ch...

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Autores principales: Karar, Jayashree, Cerniglia, George J., Lindsten, Tullia, Koumenis, Constantinos, Maity, Amit
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2012
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461816/
https://ncbi.nlm.nih.gov/pubmed/22895065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.21144
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