Inhibition of Autophagy as a Strategy to Augment Radiosensitization by the Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235

We investigated the effect of 2-methyl-2-{4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl]phenyl} propanenitrile (NVP-BEZ235) (Novartis, Basel Switzerland), a dual phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor currently being teste...

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Detalhes bibliográficos
Main Authors: Cerniglia, George J., Karar, Jayashree, Tyagi, Sonia, Christofidou-Solomidou, Melpo, Rengan, Ramesh, Koumenis, Constantinos, Maity, Amit
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502620/
https://ncbi.nlm.nih.gov/pubmed/22989521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.080408
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