Autophagy inhibition enhances colorectal cancer apoptosis induced by dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235

Phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling pathway performs a central role in tumorigenesis and is constitutively activated in many malignancies. As a novel dual PI3K/mTOR inhibitor currently undergoing evaluation in a phase I/II clinical trial, NVP-BEZ235 in...

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Publicado no:Oncol Lett
Main Authors: YANG, XIAOYU, NIU, BINGXUAN, WANG, LIBO, CHEN, MEILING, KANG, XIAOCHUN, WANG, LUONAN, JI, YINGHUA, ZHONG, JIATENG
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906634/
https://ncbi.nlm.nih.gov/pubmed/27347108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2016.4590
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