Proton beam radiation induces DNA damage and cell apoptosis in glioma stem cells through reactive oxygen species

Glioblastoma multiforme (GBM) is among the most lethal of human malignancies. Most GBM tumors are refractory to cytotoxic therapies. Glioma stem cells (GSCs) significantly contribute to GBM progression and post-treatment tumor relapse, therefore serving as a key therapeutic target; however, GSCs are...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Alan Mitteer, R., Wang, Yanling, Shah, Jennifer, Gordon, Sherika, Fager, Marcus, Butter, Param-Puneet, Jun Kim, Hyun, Guardiola-Salmeron, Consuelo, Carabe-Fernandez, Alejandro, Fan, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564801/
https://ncbi.nlm.nih.gov/pubmed/26354413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13961
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