A glucose-responsive insulin therapy protects animals against hypoglycemia

Hypoglycemia is commonly associated with insulin therapy, limiting both its safety and efficacy. The concept of modifying insulin to render its glucose-responsive release from an injection depot (of an insulin complexed exogenously with a recombinant lectin) was proposed approximately 4 decades ago...

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Vydáno v:JCI Insight
Hlavní autoři: Yang, Ruojing, Wu, Margaret, Lin, Songnian, Nargund, Ravi P., Li, Xinghai, Kelly, Theresa, Yan, Lin, Dai, Ge, Qian, Ying, Dallas-yang, Qing, Fischer, Paul A., Cui, Yan, Shen, Xiaolan, Huo, Pei, Feng, Danqing Dennis, Erion, Mark D., Kelley, David E., Mu, James
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821182/
https://ncbi.nlm.nih.gov/pubmed/29321379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97476
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