Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies

Given that many antifungal medications are susceptible to evolved resistance, there is a need for novel drugs with unique mechanisms of action. Inhibiting the essential proton pump Pma1p, a P-type ATPase, is a potentially effective therapeutic approach that is orthogonal to existing treatments. We i...

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Vydáno v:J Cheminform
Hlavní autoři: Ottilie, Sabine, Goldgof, Gregory M., Cheung, Andrea L., Walker, Jennifer L., Vigil, Edgar, Allen, Kenneth E., Antonova-Koch, Yevgeniya, Slayman, Carolyn W., Suzuki, Yo, Durrant, Jacob D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820243/
https://ncbi.nlm.nih.gov/pubmed/29464421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13321-018-0261-3
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