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Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors
Development of selective kinase inhibitors remains a challenge due to considerable amino acid sequence similarity among family members particularly in the ATP binding site. Targeting the activation loop might offer improved inhibitor selectivity since this region of kinases is less conserved. Howeve...
Enregistré dans:
| Publié dans: | Bioorg Med Chem Lett |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Elsevier Science Ltd
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5819902/ https://ncbi.nlm.nih.gov/pubmed/29409752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.01.044 |
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