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Water-Soluble Palladium Reagents for Cysteine S-Arylation under Ambient Aqueous Conditions

We report the use of a sulfonated biarylphosphine ligand (sSPhos) to promote the chemoselective modification of cysteine containing proteins and peptides with palladium reagents in aqueous medium. The use of sSPhos allowed for the isolation of several air-stable and water-soluble mono- and bis-palla...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Org Lett
Prif Awduron: Rojas, Anthony J., Pentelute, Bradley L., Buchwald, Stephen L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818991/
https://ncbi.nlm.nih.gov/pubmed/28777001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.7b01911
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