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Thermodynamic secrets of multidrug resistance: A new take on transport mechanisms of secondary active antiporters

Multidrug resistance (MDR) presents a growing challenge to global public health. Drug extrusion transporters play a critical part in MDR; thus, their mechanisms of substrate recognition are being studied in great detail. In this work, we review common structural features of key transporters involved...

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Bibliografske podrobnosti
izdano v:Protein Sci
Main Authors: Zhang, Xuejun C., Liu, Min, Lu, Guangyuan, Heng, Jie
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818768/
https://ncbi.nlm.nih.gov/pubmed/29193407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3355
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