Gα12 overexpression induced by miR16 dysregulation contributes to liver fibrosis by promoting autophagy in hepatic stellate cells

BACKGROUND & AIMS: Hepatic stellate cells (HSCs) play a role in liver fibrosis. Guanine nucleotide-binding α-subunit12 (Gα(12)) converges signals from G protein-coupled receptors whose ligand levels are elevated in the environment during liver fibrosis; however, information is lacking on the eff...

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Pubblicato in:J Hepatol
Autori principali: Kim, Kyu Min, Han, Chang Yeob, Kim, Ji Young, Cho, Sam Seok, Kim, Yun Seok, Koo, Ja Hyun, Lee, Jung Min, Lim, Sung Chul, Kang, Keon Wook, Kim, Jae Sung, Hwang, Se Jin, Ki, Sung Hwan, Kim, Sang Geon
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818314/
https://ncbi.nlm.nih.gov/pubmed/29080810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2017.10.011
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