Gα12 overexpression induced by miR16 dysregulation contributes to liver fibrosis by promoting autophagy in hepatic stellate cells

BACKGROUND & AIMS: Hepatic stellate cells (HSCs) play a role in liver fibrosis. Guanine nucleotide-binding α-subunit12 (Gα(12)) converges signals from G protein-coupled receptors whose ligand levels are elevated in the environment during liver fibrosis; however, information is lacking on the eff...

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Detalhes bibliográficos
Publicado no:J Hepatol
Main Authors: Kim, Kyu Min, Han, Chang Yeob, Kim, Ji Young, Cho, Sam Seok, Kim, Yun Seok, Koo, Ja Hyun, Lee, Jung Min, Lim, Sung Chul, Kang, Keon Wook, Kim, Jae Sung, Hwang, Se Jin, Ki, Sung Hwan, Kim, Sang Geon
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818314/
https://ncbi.nlm.nih.gov/pubmed/29080810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2017.10.011
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