Recruitment and allosteric stimulation of a histone-deubiquitinating enzyme during heterochromatin assembly

Heterochromatin formation in budding yeast is regulated by the silent information regulator (SIR) complex. The SIR complex comprises the NAD-dependent deacetylase Sir2, the scaffolding protein Sir4, and the nucleosome-binding protein Sir3. Transcriptionally active regions present a challenge to SIR...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Zukowski, Alexis, Al-Afaleq, Nouf Omar, Duncan, Emily D., Yao, Tingting, Johnson, Aaron M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818202/
https://ncbi.nlm.nih.gov/pubmed/29288197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000498
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