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NICKEL COMPOUNDS INDUCE HISTONE UBIQUITINATION BY INHIBITING HISTONE DEUBIQUITINATING ENZYME ACTIVITY

Nickel (Ni) compounds are known carcinogens but underlying mechanisms are not clear. Epigenetic changes are likely to play an important role in nickel ion carcinogenesis. Previous studies have shown epigenetic effects of nickel ions, including the loss of histone acetylation and a pronounced increas...

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Dettagli Bibliografici
Autori principali: Ke, Qingdong, Ellen, Thomas P., Costa, Max
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2424130/
https://ncbi.nlm.nih.gov/pubmed/18279901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2007.12.015
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