PML is recruited to heterochromatin during S phase and represses DAXX-mediated histone H3.3 chromatin assembly

The incorporation of the histone H3 variant, H3.3, into chromatin by the H3.3-specific chaperone DAXX and the ATP-dependent chromatin remodeling factor ATRX is a critical mechanism for silencing repetitive DNA. DAXX and ATRX are also components of promyelocytic nuclear bodies (PML-NBs), which have b...

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Bibliographic Details
Published in:J Cell Sci
Main Authors: Shastrula, Prashanth Krishna, Sierra, Isabel, Deng, Zhong, Keeney, Frederick, Hayden, James E., Lieberman, Paul M., Janicki, Susan M.
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451418/
https://ncbi.nlm.nih.gov/pubmed/30796101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.220970
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