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PML is recruited to heterochromatin during S phase and represses DAXX-mediated histone H3.3 chromatin assembly
The incorporation of the histone H3 variant, H3.3, into chromatin by the H3.3-specific chaperone DAXX and the ATP-dependent chromatin remodeling factor ATRX is a critical mechanism for silencing repetitive DNA. DAXX and ATRX are also components of promyelocytic nuclear bodies (PML-NBs), which have b...
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| Опубликовано в: : | J Cell Sci |
|---|---|
| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Company of Biologists Ltd
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6451418/ https://ncbi.nlm.nih.gov/pubmed/30796101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.220970 |
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