X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition

Heat shock protein 70 (Hsp70) and Hsp90 are molecular chaperones that play essential roles in tumor growth by stabilizing pro-survival client proteins. However, although the development of Hsp90 inhibitors has benefited from the identification of clients, such as Raf-1 proto-oncogene, Ser/Thr kinase...

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Publicado no:J Biol Chem
Main Authors: Cesa, Laura C., Shao, Hao, Srinivasan, Sharan R., Tse, Eric, Jain, Chetali, Zuiderweg, Erik R. P., Southworth, Daniel R., Mapp, Anna K., Gestwicki, Jason E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818200/
https://ncbi.nlm.nih.gov/pubmed/29255093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000634
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