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Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke

OBJECTIVE: Inhibitors of the voltage‐gated K(+) channel Kv1.3 are currently in development as immunomodulators for the treatment of autoimmune diseases. As Kv1.3 is also expressed on microglia and has been shown to be specifically up‐regulated on “M1‐like” microglia, we here tested the therapeutic h...

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Bibliografske podrobnosti
izdano v:Ann Clin Transl Neurol
Main Authors: Chen, Yi‐Je, Nguyen, Hai M., Maezawa, Izumi, Jin, Lee‐Way, Wulff, Heike
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5817832/
https://ncbi.nlm.nih.gov/pubmed/29468176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.513
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