PTEN loss promotes intratumoral androgen synthesis and tumor microenvironment remodeling via aberrant activation of RUNX2 in castration-resistant prostate cancer

PURPOSE: Intratumoral androgen synthesis (IAS) is a key mechanism promoting androgen receptor (AR)reactivation and anti-androgen resistance in castration-resistant prostate cancer (CRPC). However, signaling pathways driving aberrant IAS remain poorly understood. EXPERIMENTAL DESIGN: The effect of co...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Yang, Yinhui, Bai, Yang, He, Yundong, Zhao, Yu, Chen, Jiaxiang, Ma, Linlin, Pan, Yunqian, Hinten, Michael, Zhang, Jun, Karnes, R. Jeffrey, Kohli, Manish, Westendorf, Jennifer J., Li, Benyi, Zhu, Runzhi, Huang, Haojie, Xu, Wanhai
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816982/
https://ncbi.nlm.nih.gov/pubmed/29167276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2006
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