Androgen receptor splice variants bind to constitutively open chromatin and promote abiraterone-resistant growth of prostate cancer

Androgen receptor (AR) splice variants (ARVs) are implicated in development of castration-resistant prostate cancer (CRPC). Upregulation of ARVs often correlates with persistent AR activity after androgen deprivation therapy (ADT). However, the genomic and epigenomic characteristics of ARV-dependent...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: He, Yundong, Lu, Ji, Ye, Zhenqing, Hao, Siyuan, Wang, Liewei, Kohli, Manish, Tindall, Donald J, Li, Benyi, Zhu, Runzhi, Wang, Liguo, Huang, Haojie
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Molecular Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829742/
https://ncbi.nlm.nih.gov/pubmed/29309643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1306
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