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FOXO1 Binds to the TAU5 Motif and Inhibits Constitutively Active Androgen Receptor Splice Variants
BACKGROUND: Aberrant activation of the androgen receptor (AR) is a major factor highly relevant to castration-resistant progression of prostate cancer (PCa). FOXO1, a key downstream effector of PTEN, inhibits androgen-independent activation of the AR. However, the underlying mechanism remains elusiv...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3915545/ https://ncbi.nlm.nih.gov/pubmed/23389878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.22649 |
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